P(NMe<sub>2</sub>)<sub>3</sub>-Mediated Regioselective N-Alkylation of 2-Pyridones via Direct Deoxygenation of α-Keto Esters
Nan Wang, Yuanyuan Huang, You Zi, Mengke Wang, Weichun Huang
Abstract
A practical and regioselective direct N-alkylation of 2-pyridones is enabled by use of α-keto esters in the P(NMe 2 ) 3 -mediated deoxygenation process. The reaction proceeds under mild conditions to produce N-alkylated 2-pyridones with high selectivity and generality, and the protocol is shown to be applicable for the scale-up synthesis, which makes it promising for practical applications.
Topics & Concepts
RegioselectivityDeoxygenationAlkylationChemistrySelectivityCombinatorial chemistryGeneralityOrganic chemistryCatalysisPsychotherapistPsychologyAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods