2-(Chloromethyl)-3-phenylquinazolin-4(3H)-ones as potent anticancer agents; cytotoxicity, molecular docking and in silico studies
Leila Emami, Zeinab Faghih, Soghra Khabnadideh, Zahra Rezaei, Razieh Sabet, Ebrahim Harigh, Zahra Faghih
Topics & Concepts
QuinazolineChemistryDocking (animal)CisplatinCytotoxicityErlotinibEpidermal growth factor receptorEGFR inhibitorsIn silicoMTT assayStereochemistryIn vitroIC50Cell cultureMolecular modelMCF-7PharmacologyCancer cellBiochemistryReceptorCancerBiologyChemotherapyNursingGeneHuman breastMedicineGeneticsQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity