Recent Developments for the Ring Opening of Pyrrolidines and Unstrained Cyclic Amines via C−N Bond Cleavage
Eisuke Ota, Junichiro Yamaguchi
Abstract
Abstract In recent years, the deconstructive transformation of unstrained cyclic amines via C−N bond cleavage has emerged as a powerful strategy for expanding chemical space and facilitating the synthesis of structurally diverse molecules. Notably, advancements in the C−N bond cleavage of pyrrolidine and other unstrained cyclic amines have highlighted the significant potential of this approach in modern organic synthesis. This concept reviews recent developments in the C−N bond cleavage reaction, with a primary focus on pyrrolidines, while also exploring broader progress in related systems.
Topics & Concepts
ChemistryCyclic aminesCleavage (geology)Bond cleavageRing (chemistry)StereochemistryCombinatorial chemistryOrganic chemistryAmine gas treatingCatalysisFracture (geology)Geotechnical engineeringEngineeringAdvanced Synthetic Organic ChemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods