Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae
Lucile Pantel, Paulo Juarez, Marine Serri, Lilia Boucinha, Emilie Lessoud, Anne Lanois, Alain Givaudan, Emilie Racine, Maxime Gualtiéri
Abstract
NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most of the colistin (CST)-resistant strains.
Topics & Concepts
BiologyMutantKlebsiella pneumoniaeMicrobiologyGeneEffluxGeneticsEscherichia coliAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologySalmonella and Campylobacter epidemiology