New twists on long noncoding RNAs: from mobile elements to motile cancer cells
Tuan M. Nguyen, Sumayya Alchalabi, Oluwatoyosi Adewunmi, Ali S. Ropri, Jason I. Herschkowitz, Jeffrey M. Rosen
Abstract
The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.
Topics & Concepts
BiologyComputational biologyRNA splicingEnhancermicroRNATransposable elementLong non-coding RNAEpithelial–mesenchymal transitionAlternative splicingSmall nucleolar RNARNAGeneticsTransition (genetics)Messenger RNAGeneGene expressionGenomeCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing