Deubiquitylating enzymes in neuronal health and disease
Fatima Amer‐Sarsour, Alina Kordonsky, Yevgeny Berdichevsky, Gali Prag, Avraham Ashkenazi
Abstract
Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.
Topics & Concepts
ProteostasisDiseaseBiologyNeuroscienceProteomeFunction (biology)UbiquitinComputational biologyBioinformaticsCell biologyMedicineGeneticsGenePathologyUbiquitin and proteasome pathwaysGenetics and Neurodevelopmental DisordersEndoplasmic Reticulum Stress and Disease