Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia
Yingjie Peng, Xiaoyu Su, Benjamin Wang, Timothy Matthews, Jayasri Nanduri, Nanduri R. Prabhakar
Abstract
Carotid body (CB) sensory nerve activation is essential for sympathetic nerve excitation and hypertension in rodents treated with chronic intermittent hypoxia (CIH) simulating blood O 2 profiles during obstructive sleep apnea (OSA). Here, we report that CIH-treated mice and hemeoxygenase (HO)-2-deficient mice, which show OSA exhibit sympathetic excitation, hypertension, and CB activation. These effects are absent in Olfr78 null and Olfr78/HO-2 double null mice.
Topics & Concepts
Carotid bodyEndocrinologyInternal medicineHypoxia (environmental)Sympathetic nervous systemIntermittent hypoxiaMedicineObstructive sleep apneaSensory systemSensory nerveBlood pressureChemistryBiologyNeuroscienceElectrophysiologyOxygenOrganic chemistryNeuroscience of respiration and sleepObstructive Sleep Apnea ResearchHigh Altitude and Hypoxia