Analysis of the Streptococcus mutans Proteome during Acid and Oxidative Stress Reveals Modules of Protein Coexpression and an Expanded Role for the TreR Transcriptional Regulator
Elizabeth L. Tinder, Roberta C. Faustoferri, Andrew Buckley, Robert G. Quivey, Jonathon L. Baker
Abstract
deletion mutants. A total of 607 proteins were differentially expressed across the strains/growth conditions, and modules of coexpressed proteins were identified, which enabled mapping the acid and oxidative stress responses across S. mutans metabolism. The presence of TreR was linked to mutacin production via LytTR system signaling and to oxidative stress via mutanobactin production. The data provided by this study will guide future research elucidating S. mutans pathogenesis and developing improved preventative and treatment modalities for dental caries.
Topics & Concepts
Streptococcus mutansOxidative stressProteomeMicrobiologyVirulenceRegulatorMutantBiologyOxidative phosphorylationBioinformaticsGeneticsBacteriaBiochemistryGeneOral microbiology and periodontitis researchDental Health and Care UtilizationInfective Endocarditis Diagnosis and Management