Effect of C-terminus amidation of Aβ<sub>39–42</sub>fragment derived peptides as potential inhibitors of Aβ aggregation
Akshay Kapadia, Aesan Patel, Krishna K. Sharma, Indresh Kumar Maurya, Varinder Singh, Madhu Khullar, Rahul Jain
Abstract
studies show that the peptide interacts with the key amino acids in Aβ, which potentiate its fibrillation, thereby arresting aggregation propensity. This structural class of designed scaffolds provides impetus towards the rational development of peptide-based-therapeutics for Alzheimer's disease (AD).
Topics & Concepts
PeptideCircular dichroismChemistryFibrilPeptidomimeticCytotoxicityIn silicoViability assayAmyloid (mycology)Amino acidBiophysicsPeptide sequenceNeurotoxicityP3 peptideFluorescenceMTT assayBiochemistryCombinatorial chemistryCellIn vitroAlzheimer's diseaseAmyloid precursor proteinToxicityBiologyOrganic chemistryDiseaseInorganic chemistryPhysicsQuantum mechanicsPathologyGeneMedicineAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods