Stereo-controlled <i>anti</i>-hydromagnesiation of aryl alkynes by magnesium hydrides
Bin Wang, Derek Yiren Ong, Yihang Li, Jia Pang, Kohei Watanabe, Ryo Takita, Shunsuke Chiba
Abstract
<italic>Anti</italic>-hydromagnesiation of aryl alkynes was facilitated solely by magnesium hydride. The resulting alkenylmagnesium intermediates were functionalized with various electrophiles to afford stereochemically defined tri-substituted alkenes.
Topics & Concepts
ElectrophileArylMagnesiumHydrideChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisHydrogenAlkylCoordination Chemistry and OrganometallicsCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistry