Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients
Stephanie Hunter McMahon, Pranoti Sahasrabhojane, Jiwoong Kim, Samantha Franklin, Chia‐Chi Chang, Robert R. Jenq, Andrew Hillhouse, Samuel A. Shelburne, Jessica Galloway-Peña
Abstract
A major cause of mortality in hematologic malignancy patients is BSI. Previous studies have demonstrated that bacterial translocation from the GI microbiome is a major source of BSIs and is often preceded by increased levels of the infectious taxa in the GI (>30% abundance by 16S rRNA sequencing). In this study, we sought to better understand how domination and abundance levels of the oral and gut microbiome relate to bacteremia occurrence in acute myeloid leukemia patients. We conclude that analyses of both oral and stool samples can help identify BSI and antimicrobial resistance determinants, thus potentially improving the timing and tailoring of antibiotic treatment strategies for high-risk patients.