Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis <i>via</i> transient flow
Linden Schrecker, Joachim Dickhaut, Christian Holtze, Philipp Staehle, Marcel Vrânceanu, Klaus Hellgardt, King Kuok Hii
Abstract
Kinetic data for the Knorr pyrazole synthesis were acquired using transient flow methods, including a novel reactant stoichiometry ramping method, providing new insights into the mechanism, including autocatalysis and an unexpected intermediate.
Topics & Concepts
AutocatalysisPyrazoleTransient (computer programming)StoichiometryChemistryFlow (mathematics)Reaction mechanismCombinatorial chemistryMechanism (biology)CatalysisStereochemistryComputer scienceOrganic chemistryMechanicsPhysicsOperating systemQuantum mechanicsInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisMicrowave-Assisted Synthesis and Applications