Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation
Jan‐Niklas May, Susanne K. Golombek, Maike Baues, Anshuman Dasgupta, Natascha Drude, Anne Rix, Dirk Rommel, Saskia von Stillfried, Lia Appold, Robert Pola, Michal Pechar, Louis van Bloois, Gert Storm, Alexander J. C. Kuehne, Felix Gremse, Benjamin Theek, Fabian Kießling, Twan Lammers
Abstract
: BBB opening via sonopermeation enables safe and efficient delivery of nanomedicine formulations to and into the brain. When looking at accumulation and penetration (and when neglecting issues such as drug loading capacity and therapeutic efficacy) smaller-sized DDS are found to be more suitable for drug delivery across the BBB than larger-sized DDS. These findings are valuable for better understanding and further developing nanomedicine-based strategies for the treatment of CNS disorders.