Fructooligosaccharide supplementation alleviated the pathological immune response and prevented the impairment of intestinal barrier in DSS-induced acute colitis mice
Minjing Liao, Yuanfang Zhang, Yilan Qiu, Zhengchun Wu, Zhihong Zhong, Xiaoqi Zeng, Yiliang Zeng, Li Xiong, Yu Wen, Rushi Liu
Abstract
. Both FOS and synbiotic mitigated DSS-induced loss of mucus protein (MUC2) and epithelium tight junction proteins (ZO-1, Occluding, Claudin1) in colon mucosa. The expression of pro-inflammatory cytokines (IL-6 and TNF-α) was decreased by FOS or synbiotic treatment, while the expression of Tbx21 and IL-10 was increased. The results suggested that the modulation of gut microbiota by FOS or synbiotic supplementation could decrease the inflammation potential of colonized commensals, which prevented the impairment of the intestinal barrier and induced a regulation of immune response in DSS-induced acute colitis mice.
Topics & Concepts
FructooligosaccharideColitisDysbiosisImmune systemInflammatory bowel diseaseSynbioticsPrebioticGut floraInflammationImmunologyMucin 2Intestinal mucosaProinflammatory cytokineBiologyInternal medicineMedicineProbioticDiseaseGene expressionBacteriaBiochemistryGeneticsGeneGut microbiota and healthHelicobacter pylori-related gastroenterology studiesInflammatory Bowel Disease