Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis
Tiezhu Shi, Xiao Li, Jia-Hao Zheng, Zong‐Hao Duan, Yin Yin Ooi, Yan Gao, Qi Wang, Jian‐Yu Yang, Lulu Wang, Linli Yao
Topics & Concepts
KRASCancer researchGene knockdownPancreatic cancerOncogeneMAPK/ERK pathwaySignal transductionMedicineCXCR4BiologyCancerChemokineInflammationImmunologyCell biologyColorectal cancerCell cultureInternal medicineCell cycleGeneticsFibroblast Growth Factor ResearchProteoglycans and glycosaminoglycans researchImmune cells in cancer