A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance
Luis Tobalina, Joshua Armenia, Elsa Irving, Mark J. O’Connor, Josep V. Forment
Topics & Concepts
MedicineReversionCancerDNA repairCancer researchBRCA2 ProteinMutationBreast cancerPancreatic cancerGeneProstate cancerOvarian cancerOlaparibGeneticsInternal medicineGermline mutationBiologyPolymerasePoly ADP ribose polymerasePhenotypePARP inhibition in cancer therapyDNA Repair MechanismsBRCA gene mutations in cancer