Ferrocene-triazole conjugates: do we know why they are biologically active?
Mariola Koszytkowska‐Stawińska, Włodzimierz Buchowicz
Abstract
azide-alkyne cycloaddition reactions. The data are summarized according to the type of activity (anticancer, antibacterial and/or antifungal, antiprotozoal, and other effects). The results of studies concerning the understanding of the role of the ferrocene core in their biological activity are highlighted. While generally the mode of action of these organometallic species remains unclear, the importance of redox properties of ferrocene has been postulated in several cases.
Topics & Concepts
FerroceneConjugateCombinatorial chemistryChemistryTriazoleOrganic chemistryMathematicsMathematical analysisElectrodePhysical chemistryElectrochemistryFerrocene Chemistry and ApplicationsClick Chemistry and ApplicationsSynthesis and Biological Evaluation