Zwitterionic-to-cationic charge conversion polyprodrug nanomedicine for enhanced drug delivery
Sheng Wang, Fuwu Zhang, Guocan Yu, Zhantong Wang, Orit Jacobson, Ying Ma, Rui Tian, Hongzhang Deng, Weijing Yang, Zhiyi Chen, Xiaoyuan Chen
Abstract
This ZTC method offers a strategy to promote the drug delivery efficiency and therapeutic efficacy, which is promising for the development of cancer nanomedicines.
Topics & Concepts
NanomedicineInternalizationDrug deliveryCamptothecinZwitterionProdrugNanoparticleCationic polymerizationDrugNanotechnologyDruggabilityCationic liposomeMaterials scienceChemistryPharmacologyMedicineCellBiochemistryTransfectionOrganic chemistryMoleculeGeneNanoparticle-Based Drug DeliveryPolymer Surface Interaction StudiesNanoplatforms for cancer theranostics