Design, synthesis, anticancer evaluation, and <i>in silico</i> ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents
Anas Ramadan Kotb, Abdallah E. Abdallah, Hazem Elkady, Ibrahim H. Eissa, Mohammed S. Taghour, Dina A. Bakhotmah, Tamer M. Abdelghany, Mohamed Ayman El‐Zahabi
Abstract
ADMET and toxicity studies showed that most of tested candidates have a good profile of drug-likeness and low toxicity potential.
Topics & Concepts
In silicoThalidomideCombinatorial chemistryChemistryComputational biologyPharmacologyStereochemistryBiochemistryBiologyImmunologyGeneMultiple myelomaMultiple Myeloma Research and TreatmentsCancer therapeutics and mechanismsProtein Degradation and Inhibitors