Organocatalytic asymmetric formal oxidative coupling for the construction of all-aryl quaternary stereocenters
Zhiyang Li, Yichen Li, Xingguang Li, Mandi Wu, Ming‐Liang He, Jianwei Sun
Abstract
-directing group serve as the key intermediate. The precise loading of DDQ is critical to the high enantioselectivity. The chiral products have also been demonstrated as promising antiviral agents.
Topics & Concepts
StereocenterEnantioselective synthesisArylQuaternary carbonChemistryOxidative coupling of methaneOrganocatalysisQuinoneCoupling (piping)Combinatorial chemistryStereochemistryOrganic chemistryCatalysisMaterials scienceAlkylMetallurgySynthesis of Indole DerivativesAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacology