Enantioselective Intramolecular Iridium-Catalyzed Cyclopropanation of α-Carbonyl Sulfoxonium Ylides
Lucas Vidal, Pan‐Pan Chen, Eva Nicolas, Andrew Hackett, Craig M. Robertson, K. N. Houk, Christophe Aïssa
Abstract
face of the olefin preferably attacks an iridium carbene intermediate in an asynchronous concerted step that is independent of the geometry of the olefin.
Topics & Concepts
CyclopropanationIntramolecular forceIridiumEnantioselective synthesisChemistryCarbeneOlefin fiberCatalysisMedicinal chemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions