New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies
Yasmin M. Syam, Manal M. Anwar, Somaia S. Abd El‐Karim, Samia A. Elseginy, Basma M. Essa, Tamer M. Sakr
Abstract
I-SQ compound 10a to study the pharmacokinetic profile of this set of compounds. The biodistribution pattern hit the target protein since the tracer accumulated mainly in the visceral organs where DPP-4 is secreted in a high-level, thus with consequent stimulation of insulin secretion, leading to the target hypoglycemic effect.
Topics & Concepts
QuinoxalineSulfonamideCombinatorial chemistryChemistryScaffoldDistribution (mathematics)StereochemistryOrganic chemistryComputer scienceMathematicsDatabaseMathematical analysisSynthesis and Biological EvaluationNanomaterials for catalytic reactionsPharmacological Receptor Mechanisms and Effects