Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm
Jakub Toczek, Parnaz Boodagh, Nowshin Sanzida, Mean Ghim, Mani Salarian, Kiran Gona, Gunjan Kukreja, Saranya Rajendran, Linyan Wei, Jinah Han, Jiasheng Zhang, Jaejoon Jung, Morven Graham, Xinran Liu, Mehran M. Sadeghi
Abstract
By establishing the feasibility of CT-based molecular imaging of phagocytic activity in AAA, this study links the inflammatory signal on early time point images to AAA evolution. This readily available technology overcomes an important barrier to cross-sectional, longitudinal and outcome studies, not only in AAA, but also in other cardiovascular pathologies and facilitates the evaluation of modulatory interventions, and ultimately upon clinical translation, patient management.
Topics & Concepts
Abdominal aortic aneurysmInflammationPathogenesisMedicineMacrophageAortic aneurysmAneurysmComputed tomographyPathologyRadiologyInternal medicineBiologyIn vitroBiochemistryAortic aneurysm repair treatmentsAbdominal vascular conditions and treatmentsInfectious Aortic and Vascular Conditions