Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life
Jussara M. do Carmo, Ana Carolina Mieko Omoto, Xuemei Dai, Sydney P. Moak, Gabriela S. Mega, Xuan Li, Zhen Wang, Alan J. Mouton, John E. Hall, Alexandre A. da Silva
Abstract
Parental obesity contributes to diastolic dysfunction in young offspring (1–3 days after weaning) in a sex-dependent manner, as well as reduced cardiac SIRT3 expression and altered mitochondrial bioenergetics, resting Ca 2+ levels, and reduced phospholamban protein levels.
Topics & Concepts
OffspringInternal medicineEndocrinologyPhospholambanWeaningBiologyLeptinCardiac function curveDiastoleObesitySIRT3Blood pressureMedicineCalciumPregnancyHeart failureSirtuinBiochemistryAcetylationGeneGeneticsAdipose Tissue and MetabolismCardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity