Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
Dominic Denk, Valentina Petrocelli, Claire Conche, Moritz Drachsler, Paul K. Ziegler, Angela Braun, Alena Kress, Adele M. Nicolas, Kathleen Mohs, Christoph Becker, Markus F. Neurath, Henner F. Farin, Christian J. Buchholz, Pénélope A. Andreux, Chris Rinsch, Florian R. Greten
Abstract
Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Denk et al. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8 + T cells, resulting in generation regenerative stem cell-like memory (T SCM ) cells with enhanced antitumor properties.
Topics & Concepts
MitophagyCancer researchStem cellBiologyAdoptive cell transferCell biologyMitochondrionPINK1T cellAutophagyImmune systemImmunologyApoptosisBiochemistryPomegranate: compositions and health benefitsBioactive Compounds in PlantsMesenchymal stem cell research