Downregulation of microRNA-200c-3p alleviates the aggravation of venous thromboembolism by targeting serpin family C member 1
Xiaorong Jian, Dehua Yang, Li Wang, Hongxiang Wang
Abstract
. Histological examination through hematoxylin-eosin staining revealed that miR-200c-3p downregulation markedly inhibited the formation of thrombus in IVC of rats. Additionally, miR-200c-3p was upregulated while SERPINC1 was downregulated in serum and inferior vena cava of VTE rats as well as in plasma of patients with VTE. Linear regression analysis demonstrated that miR-200c-3p expression was negatively correlated to SERPINC1 expression in VTE rats and patients with VTE. Our study determines the previously unelucidated function of miR-200c-3p in VTE, which might provide a potential novel insight for the treatment of VTE.
Topics & Concepts
SerpinDownregulation and upregulationmicroRNAVenous thromboembolismFamily memberMedicineInternal medicineBiologyGeneticsGeneThrombosisFamily medicineCancer-related molecular mechanisms researchExtracellular vesicles in diseaseBlood Coagulation and Thrombosis Mechanisms