Hypochlorous acid triggered fluorescent probes for<i>in situ</i>imaging of a psoriasis model
Peng Wei, Yu Guo, Lingyan Liu, Xiaojun Zhou, Tao Yi
Abstract
Two turn-on fluorescent probes based on Oxazine 1 were developed for the detection of HOCl. The selected probe G2 can not only detect basal HOCl in HL-60 cells, but also identify HOCl in a mouse model imiquimod induced psoriasis.
Topics & Concepts
Hypochlorous acidPsoriasisReactive oxygen speciesInflammationPathogenesisChemistryFluorescenceImiquimodIn situMedicineImmunologyBiochemistryOrganic chemistryQuantum mechanicsPhysicsMolecular Sensors and Ion DetectionClick Chemistry and ApplicationsInflammatory mediators and NSAID effects