Biocompatibility, uptake and subcellular localization of bacterial magnetosomes in mammalian cells
Frank Mickoleit, Cornelia Jörke, Stefan Geimer, Denis S. Maier, Jörg P. Müller, Johanna Demut, Christine Gräfe, Dirk Schüler, Joachim H. Clement
Abstract
Treatment of mammalian cells with isolated bacterial magnetosomes indicated biocompatibility. Upon incubation, particles are internalized and located in endolysosomes, thereby magnetizing the cells in amounts sufficient for magnetic separation.
Topics & Concepts
BiocompatibilityMagnetosomeSubcellular localizationChemistryCell biologyBiophysicsBiologyBacteriaCytoplasmGeneticsOrganic chemistryGeomagnetism and Paleomagnetism StudiesMagnetic and Electromagnetic EffectsCharacterization and Applications of Magnetic Nanoparticles