Macroautophagy/autophagy promotes resistance to KRASG12D-targeted therapy through glutathione synthesis
Leng Han, Lingjun Meng, Jiao Liu, Yangchun Xie, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yuanyuan Jia, Enyong Dai
Abstract
-targeted therapy resistance by inhibiting autophagy-dependent glutathione synthesis.
Topics & Concepts
AutophagyGlutathioneCancer researchCell biologyBiologyChemistryMedicineBiochemistryApoptosisEnzymeAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseasePhagocytosis and Immune Regulation