Breast Tumor-Derived Exosomal MicroRNA-200b-3p Promotes Specific Organ Metastasis Through Regulating CCL2 Expression in Lung Epithelial Cells
Pengfei Gu, Mayu Sun, Lei Li, Yang Yang, Zheshun Jiang, Yang Ge, Wenbo Wang, Wei Mu, Hui Wang
Abstract
, which may involved in the regulation of AKT/NF-κB/CCL2 cascades. Therefore, our study suggest that CCL2 expression in the lung was regulated by BC-derived exosomal microRNA, which primed the pre-metastastatic niche and may be a prognostic marker for the development of BC lung metastasis.
Topics & Concepts
MicrovesiclesMetastasismicroRNACCL2Cancer researchSchematicLungImmunosuppressionMedicineChemokineBiologyPathologyImmune systemImmunologyCancerInternal medicineGeneEngineeringBiochemistryElectronic engineeringExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases