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Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR

Mohammed M. S. Wassel, Yousry A. Ammar, Gameel A. M. El‐Hag Ali, Amany Belal, Ahmed B. M. Mehany, Ahmed Ragab

2021Bioorganic Chemistry74 citationsDOI

Topics & Concepts

ChemistryAdamantaneErlotinibLapatinibStereochemistryT790MIC50MorpholineDocking (animal)Lead compoundADMEEGFR inhibitorsMutantIn vitroEpidermal growth factor receptorCombinatorial chemistryBiochemistryMedicinal chemistryReceptorOrganic chemistryCancerInternal medicineNursingGeneGefitinibMedicineTrastuzumabBreast cancerSynthesis and biological activitySynthesis of heterocyclic compoundsLung Cancer Treatments and Mutations
Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR | Litcius