Concise total synthesis of (+)-Zeylenone with antitumor activity and the structure–activity relationship of its derivatives
Zhonghao Sun, Shuxian Yang, Chengfang Xu, Fan Yi, Li Cao, Yu Tian, Jiahao Lin, Xudong Xu
Topics & Concepts
ChemistryDihydroxylationNatural productSubstituentStereochemistryTotal synthesisPotencyQuinic acidStructure–activity relationshipPositive controlAldol reactionYield (engineering)Chirality (physics)In vitroEnantioselective synthesisBiochemistryCatalysisTraditional medicineMaterials scienceQuarkNambu–Jona-Lasinio modelQuantum mechanicsPhysicsChiral symmetry breakingMedicineMetallurgyTraditional and Medicinal Uses of AnnonaceaeMicrobial Natural Products and BiosynthesisPhytochemical compounds biological activities