Patient-derived parathyroid organoids as a tracer and drug-screening application model
Milou E. Noltes, Luc Sondorp, Laura Kracht, Inês F. Antunes, René Wardenaar, Wendy Kelder, Annelies Kemper, Wiktor Szymański, Wouter T. Zandee, Liesbeth Jansen, Adrienne H. Brouwers, Robert P. Coppes, Schelto Kruijff
Abstract
Tc-sestamibi. These data show the functionality of PTOs resembling the parathyroid. This PTO model recapitulates the originating tissue on gene and protein expression and functionality, paving the way for future physiology studies and therapeutic target and tracer discovery.
Topics & Concepts
OrganoidBiologyTRACERDrugComputational biologyPharmacologyCell biologyNuclear physicsPhysicsParathyroid Disorders and TreatmentsGenetic Syndromes and ImprintingRenal and related cancers