Enantioselective total synthesis of (−)-myrifabral A and B
Tyler J. Fulton, Anthony Chen, Michael D. Bartberger, Brian M. Stoltz
Abstract
-acyl iminium ion cyclization forged the cyclohexane fused tricyclic core, while vinyl boronate cross metathesis and oxidation afforded the lactol ring of (-)-myrifabral A. Adaptation of previously reported conditions allowed for the conversion of (-)-myrifabral A to (-)-myrifabral B.
Topics & Concepts
Enantioselective synthesisStereochemistryTotal synthesisChemistryCatalysisCombinatoricsOrganic chemistryMathematicsAdvanced Synthetic Organic ChemistryChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacology