CK2 inhibition, lipophilicity and anticancer activity of new <i>N</i><sup>1</sup><i>versus N</i><sup>2</sup>-substituted tetrabromobenzotriazole regioisomers
Ahmed El-Kardocy, Yaser A. Mostafa, Noha Mohamed, Mohammad Nabil Abo-Zeid, Nivin A. Hassan, Helal F. Hetta, Abu‐Baker M. Abdel‐Aal
Abstract
Both the type and position of polar group substitutions in polybrominated benzotriazoles dramatically change their lipophilicity, kinase inhibition and anticancer activity.
Topics & Concepts
ChemistryLipophilicityStructural isomerStereochemistryMedicinal chemistryChronic Myeloid Leukemia TreatmentsSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds