Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation
Somaia S. Abd El‐Karim, Manal M. Anwar, Nesreen S. Ahmed, Yasmin M. Syam, Samia A. Elseginy, Hanan F. Aly, Eman A. Younis, Wagdy K. B. Khalil, Kawkab A. Ahmed, Faten F. Mohammed, Maha Z. Rizk
Topics & Concepts
ChemistryAcetylcholinesteraseDocking (animal)DPPHGlutathionePharmacologyBenzofuranStereochemistryQuantitative structure–activity relationshipAntioxidantAcute toxicityDonepezilBiochemistryEnzymeToxicityOrganic chemistryInternal medicineMedicineDementiaDiseaseNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity