Self-glucose feeding hydrogels by enzyme empowered degradation for 3D cell culture
Mehrzad Zargarzadeh, Ana Sofia Silva, Cláudia Nunes, Manuel A. Coimbra, Catarina A. Custódio, João F. Mano
Abstract
biocompatibility and biodegradability of laminaran-based hydrogels were explored for the first time. The self-feeding hydrogels exhibited high potential in cell survival compared to native cell-laden laminaran hydrogels over two weeks of sub-cutaneous implantation. Such bioscaffolds with enzyme-empowered degradation capacity can be applied in diverse biotechnological contexts such as tissue regeneration devices, biofactories, disease models, and cell delivery systems.
Topics & Concepts
Self-healing hydrogelsMesenchymal stem cellCell encapsulationBiocompatibility3D cell cultureCell cultureChemistryCellTissue engineeringCell biologyBiochemistryBiodegradationPolysaccharideMaterials scienceBiologyBiomedical engineeringPolymer chemistryMedicineOrganic chemistryGeneticsHydrogels: synthesis, properties, applications3D Printing in Biomedical ResearchSilk-based biomaterials and applications