Physiological responses to 9 hours of heat exposure in young and older adults. Part II: Autophagy and the acute cellular stress response
James J. McCormick, Robert D. Meade, Kelli E. King, Sean R. Notley, Ashley P. Akerman, Gregory W. McGarr, Brodie J. Richards, Emma R. McCourt, Pierre Boulay, Ronald J. Sigal, Glen P. Kenny
Abstract
We demonstrate for the first time that peripheral blood mononuclear cells from older adults exhibit signs of autophagic impairments during daylong (9 h) heat exposure relative to their younger counterparts. This was paired with greater apoptotic signaling and inflammatory responses, and an inability to stimulate components of the heat shock response. Thus, autophagic dysregulation during prolonged heat exposure may contribute to age-related heat vulnerability during hot weather and heat waves.
Topics & Concepts
AutophagyYoung adultApoptosisHeat shock proteinInflammationMedicineHeat shockWestern blotPeripheral blood mononuclear cellInternal medicineEndocrinologySenescenceAgeingHsp70ImmunologyBiologyBiochemistryIn vitroGeneAutophagy in Disease and TherapyAdipose Tissue and MetabolismHydrogen's biological and therapeutic effects