Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity
Ross J. Collins, Hyun-Ah Lee, D. Heulyn Jones, Jonathan M. Elkins, Jason A. Gillespie, Carys Thomas, Alex G. Baldwin, Kimberley Jones, Loren Waters, Marie Paine, John Atack, Simon E. Ward, Olivera Grubisha, David Foley
Abstract
pharmacological tools for the study of LIMK function in cell biology.
Topics & Concepts
CofilinChemistryKinaseIn vitroIn vivoSmall moleculeBiochemistryPhosphorylationEnzymeIn vitro toxicologyCell biologyCellBiologyActin cytoskeletonCytoskeletonBiotechnologyCellular Mechanics and InteractionsCardiomyopathy and Myosin StudiesBiotechnology and Related Fields