Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice
François Marcouiller, Alexandra Jochmans‐Lemoine, Gauthier Ganouna‐Cohen, Mathilde Mouchiroud, Mathieu Laplante, André Marette, Aïda Bairam, Vincent Joseph
Abstract
We assessed fasting glycemic control, and tolerance to insulin and glucose in male and female mice exposed to intermittent hypoxia. IH improves glucose tolerance in males but had opposite effects in females. This response was amplified following ovariectomy in females and prevented by estradiol supplementation. Metabolic consequences of IH differ between males and females and are regulated by estradiol in female mice.
Topics & Concepts
Internal medicineEndocrinologyOvariectomized ratGlycogenGlucose homeostasisInsulinIntermittent hypoxiaCarbohydrate metabolismBiologyGlucose tolerance testImpaired glucose toleranceInsulin resistanceHormoneMedicineObstructive sleep apneaObstructive Sleep Apnea ResearchNeuroscience of respiration and sleepHigh Altitude and Hypoxia