Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep
Paolo Contessotto, Doriana Orbanić, Mark Da Costa, Chunsheng Jin, Peter Owens, Sandrine Chantepie, Clizia Chinello, John Newell, Fulvio Magni, Dulce Papy-García, Niclas G. Karlsson, Michelle Kilcoyne, Peter Dockery, José Carlos Rodríguez‐Cabello, Abhay Pandit
Abstract
cardiomyocytes in the border zone of the infarct. We propose that our customized ECM favors cardiomyocyte preservation in the border zone by modulating the ischemic core and a marked functional recovery. The functional benefits obtained by the timely injection of the ELRs-hydrogel in a clinically relevant MI model support the potential utility of this treatment for further clinical translation.
Topics & Concepts
ElastinMyocardial infarctionExtracellular matrixLigationAngiogenesisIn vivoStromal cellIschemic cardiomyopathyFibrosisMedicineMyofibroblastBiomedical engineeringPathologyChemistryCardiologyHeart failureCancer researchSurgeryEjection fractionBiologyBiochemistryBiotechnologyTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical ApplicationsCardiac Fibrosis and Remodeling