Senescent melanocytes driven by glycolytic changes are characterized by melanosome transport dysfunction
Young Joon Park, Jin Cheol Kim, Yeongeun Kim, Yul Hee Kim, Soon Sang Park, Charlotte Muther, Agnès Tessier, Gimyung Lee, Gaëlle Gendronneau, Sandra Forestier, Youcef Ben-Khalifa, Tae Jun Park, Hee Young Kang
Abstract
These results demonstrate that senescent melanocytes are characterized by glycolytic metabolism changes and a defective melanosome transport process, which may be related to impaired mitochondrial function, highlighting the importance of metabolic reprogramming in regulating melanocyte senescence.
Topics & Concepts
MelanosomeMelanocyteSenescenceMelaninCell biologyBiologyGlycolysisDownregulation and upregulationMetabolismMelanomaBiochemistryCancer researchGenemelanin and skin pigmentationSkin Protection and AgingCircadian rhythm and melatonin