Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors
William J. McDaid, Nikolai M. Lissin, Ellen Pollheimer, Michelle K. Greene, Adam Leach, Peter Smyth, Giovanna Bossi, Daniel B. Longley, David K. Cole, Christopher J. Scott
Abstract
data demonstrate the potential of targeting tumour-restricted peptide-HLA epitopes using high affinity TCR-conjugated nanoparticles, representing a novel treatment strategy to deliver therapeutic drugs specifically to cancer cells.
Topics & Concepts
DocetaxelT-cell receptorCancer cellEpitopeAntigenCancer researchPeptideReceptorT cellIn vitroChemistryCancerMaterials scienceImmunologyMedicineImmune systemBiochemistryInternal medicineImmunotherapy and Immune ResponsesCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies Research