Photoinduced Pd-Catalyzed Dearomative 2,5-Difunctionalizition of Furans via Cascade C–C/C–O Bond Formation
Fen Long, Kai Jiang, Weiwei Song, Wenkun Luo, Biaolin Yin
Abstract
We report an efficient and mild approach for radical dearomatization via photoinduced palladium-catalyzed reaction of three components (i.e., furans, alcohols, and bromoalkanes). In this strategy, various functionalized spiro-heterocycles were prepared from furans in one step via cascade C-C/C-O bond formation under redox neutral conditions.
Topics & Concepts
ChemistryCascadeCatalysisPalladiumCascade reactionRedoxCombinatorial chemistryTriple bondMedicinal chemistryPhotochemistryOrganic chemistryDouble bondChromatographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions