Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in <i>Leishmania</i>
Bryan C. Jensen, Isabelle Phan, Jacquelyn McDonald, Aakash Sur, Mark A. Gillespie, Jeffrey A. Ranish, Marilyn Parsons, Peter J. Myler
Abstract
and related trypanosomatids. Here, we describe a new J-binding protein (JBP3) associated with three different protein complexes that are reminiscent of those involved in the control of transcription in other eukaryotes. However, the parasite complexes have been reprogrammed to regulate transcription and gene expression in trypanosomatids differently than in the mammalian hosts, providing new opportunities to develop novel chemotherapeutic treatments against these important pathogens.
Topics & Concepts
ChromatinTranscription (linguistics)DNALink (geometry)LeishmaniaBiologyGeneticsCell biologyComputer scienceWorld Wide WebComputer networkPhilosophyLinguisticsParasite hostingResearch on Leishmaniasis StudiesInsect Resistance and GeneticsTrypanosoma species research and implications