miR-146b-5p Enhances the Sensitivity of NSCLC to EGFR Tyrosine Kinase Inhibitors by Regulating the IRAK1/NF-κB Pathway
Yinan Liu, Meng‐Feng Tsai, Shang‐Gin Wu, Tzu‐Hua Chang, Tzu‐Hsiu Tsai, Chien‐Hung Gow, Hsin‐Yi Wang, Jin‐Yuan Shih
Abstract
production. In conclusion, miR-146b-5p/IRAK1/NF-κB signaling is important in promoting EGFR TKI resistance, and miR-146b-5p may be a useful tool for overcoming EGFR TKI resistance.
Topics & Concepts
MedicineCancer researchLung cancerEpidermal growth factor receptormicroRNATyrosine kinaseEctopic expressionOsimertinibApoptosisTyrosine-kinase inhibitorNF-κBKinaseCancerInternal medicineReceptorBiologyInflammationCell cultureCell biologyErlotinibGeneBiochemistryGeneticsCancer-related molecular mechanisms researchQuinazolinone synthesis and applicationsLung Cancer Treatments and Mutations