SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux
Feiye Zhou, Linlin Zhang, Ke-Cheng Zhu, Mengyao Bai, Yuqing Zhang, Qin Zhu, Shushu Wang, Chunxiang Sheng, Miaomiao Yuan, Yun Liu, Jieli Lu, Li Shao, Xiao Wang, Libin Zhou
Abstract
SIRT2 ablation inhibits GSIS through blocking GKRP protein degradation and promoting ALDOA protein degradation, resulting in a decrease in glycolytic flux.
Topics & Concepts
GlycolysisFlux (metallurgy)SIRT2SecretionInsulinInternal medicineEndocrinologyChemistryAblationCell biologyBiologyMetabolismBiochemistryMedicineSirtuinEnzymeOrganic chemistryNAD+ kinaseSirtuins and Resveratrol in MedicineDiet, Metabolism, and DiseaseEndoplasmic Reticulum Stress and Disease