Small molecular adjuvants repurpose antibiotics towards Gram-negative bacterial infections and multispecies bacterial biofilms
Rajib Dey, Sudip Mukherjee, Riya Mukherjee, Jayanta Haldar
Abstract
Gram-negative bacteria pose a significant challenge due to two major resistance elements: impermeability of the outer membrane and the overexpression of efflux pumps, contributing to antibiotic resistance. SMA tackles both and aids in antibiotic rejuvenation.
Topics & Concepts
EffluxAntibioticsBiofilmMicrobiologyAntibiotic resistanceStaphylococcus aureusAdjuvantBacteriaBiologyChemistryBiochemistryImmunologyGeneticsAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentAntimicrobial agents and applications