GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A
Hui Yang, Xiaocen Liu, Xiaolong Zhu, Mengying Zhang, Yingying Wang, Mingzhe Ma, Kun Lv
Abstract
. Mechanistically, this study identified that GINS1 physically interacts with TOP2A. GINS1 promotes glioma cell proliferation and migration through USP15-mediated deubiquitination of TOP2A protein. Our results delineate the clinical significance of GINS1 in glioma and the regulatory mechanisms involved in glioma cell proliferation and migration. This work provides potential therapeutic targets for glioma treatment.
Topics & Concepts
GliomaCell growthDownregulation and upregulationCancer researchCell biologyBiologyGene knockdownChemistryApoptosisGeneticsGeneDNA Repair MechanismsGlioma Diagnosis and TreatmentMicrotubule and mitosis dynamics