Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2
Erica L. Stewart, Claudio Counoupas, Matt D. Johansen, Duc Hai Nguyen, Stefan Miemczyk, Nicole G. Hansbro, Kia C. Ferrell, Anneliese S. Ashhurst, Sibel Alca, Caroline L. Ashley, Megan Steain, Warwick J. Britton, Philip M. Hansbro, Nikolai Petrovsky, James A. Triccas
Abstract
T cells that were not observed in IM-vaccinated mice. This study provides a detailed view of the lung-resident cellular response to IT vaccination against SARS-CoV-2 and demonstrates the importance of delivery site selection in the development of vaccine candidates.
Topics & Concepts
ImmunologyVaccinationImmune systemAdjuvantImmunizationMedicineVirologyImmunitySARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune ResponsesVaccine Coverage and Hesitancy